Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease
Identifieur interne : 000280 ( Main/Corpus ); précédent : 000279; suivant : 000281Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease
Auteurs : Joseph Ferrara ; Alan Diamond ; Christine Hunter ; Anthony Davidson ; Michael Almaguer ; Joseph JankovicSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2010-03.
Abstract
Objective Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLSM, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance. Methods We prospectively analysed QLSM scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively. Results Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLSM. Specifically, QLSM items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve. Conclusion Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.
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DOI: 10.1136/jnnp.2009.184127
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title><author><name sortKey="Ferrara, Joseph" sort="Ferrara, Joseph" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Diamond, Alan" sort="Diamond, Alan" uniqKey="Diamond A" first="Alan" last="Diamond">Alan Diamond</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Davidson, Anthony" sort="Davidson, Anthony" uniqKey="Davidson A" first="Anthony" last="Davidson">Anthony Davidson</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Almaguer, Michael" sort="Almaguer, Michael" uniqKey="Almaguer M" first="Michael" last="Almaguer">Michael Almaguer</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: josephj@bcm.tmc.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C08850013797AFD8A24B99253A02F24B1CDF6385</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1136/jnnp.2009.184127</idno><idno type="url">https://api.istex.fr/document/C08850013797AFD8A24B99253A02F24B1CDF6385/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title><author><name sortKey="Ferrara, Joseph" sort="Ferrara, Joseph" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Diamond, Alan" sort="Diamond, Alan" uniqKey="Diamond A" first="Alan" last="Diamond">Alan Diamond</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Davidson, Anthony" sort="Davidson, Anthony" uniqKey="Davidson A" first="Anthony" last="Davidson">Anthony Davidson</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Almaguer, Michael" sort="Almaguer, Michael" uniqKey="Almaguer M" first="Michael" last="Almaguer">Michael Almaguer</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><mods:affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: josephj@bcm.tmc.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2010-03">2010-03</date><biblScope unit="volume">81</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">C08850013797AFD8A24B99253A02F24B1CDF6385</idno><idno type="DOI">10.1136/jnnp.2009.184127</idno><idno type="href">jnnp-81-315.pdf</idno><idno type="ArticleID">jnnp184127</idno><idno type="PMID">19726415</idno><idno type="local">jnnp;81/3/315</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLSM, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance. Methods We prospectively analysed QLSM scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively. Results Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLSM. Specifically, QLSM items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve. Conclusion Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Joseph Ferrara</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Alan Diamond</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Christine Hunter</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Anthony Davidson</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Michael Almaguer</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Joseph Jankovic</name><affiliations><json:string>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string><json:string>E-mail: josephj@bcm.tmc.edu</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Research paper</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Deep Brain Stimulation (DBS)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health status</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>QLSM</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurosurgery</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>scales</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Objective Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLSM, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance. Methods We prospectively analysed QLSM scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively. Results Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLSM. Specifically, QLSM items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve. Conclusion Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.</abstract><qualityIndicators><score>8.413</score><pdfVersion>1.6</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>1633</abstractCharCount><pdfWordCount>4117</pdfWordCount><pdfCharCount>28892</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>233</abstractWordCount></qualityIndicators><title>Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title><pmid><json:string>19726415</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>81</volume><pages><first>315</first></pages><issn><json:string>0022-3050</json:string></issn><issue>3</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1136/jnnp.2009.184127</json:string></doi><id>C08850013797AFD8A24B99253A02F24B1CDF6385</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C08850013797AFD8A24B99253A02F24B1CDF6385/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C08850013797AFD8A24B99253A02F24B1CDF6385/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C08850013797AFD8A24B99253A02F24B1CDF6385/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2009-09-01</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title><author><persName><forename type="first">Joseph</forename><surname>Ferrara</surname></persName><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Alan</forename><surname>Diamond</surname></persName><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Christine</forename><surname>Hunter</surname></persName><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Anthony</forename><surname>Davidson</surname></persName><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Almaguer</surname></persName><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author corresp="yes"><persName><forename type="first">Joseph</forename><surname>Jankovic</surname></persName><email>josephj@bcm.tmc.edu</email><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2010-03"></date><biblScope unit="volume">81</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope></imprint></monogr><idno type="istex">C08850013797AFD8A24B99253A02F24B1CDF6385</idno><idno type="DOI">10.1136/jnnp.2009.184127</idno><idno type="href">jnnp-81-315.pdf</idno><idno type="ArticleID">jnnp184127</idno><idno type="PMID">19726415</idno><idno type="local">jnnp;81/3/315</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009-09-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objective Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLSM, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance. Methods We prospectively analysed QLSM scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively. Results Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLSM. Specifically, QLSM items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve. Conclusion Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Deep Brain Stimulation (DBS)</term></item><item><term>Parkinson's disease</term></item><item><term>quality of life</term></item><item><term>health status</term></item><item><term>QLSM</term></item><item><term>movement disorders</term></item><item><term>neurosurgery</term></item><item><term>scales</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-09-01">Created</change><change when="2010-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C08850013797AFD8A24B99253A02F24B1CDF6385/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp184127</article-id><article-id pub-id-type="doi">10.1136/jnnp.2009.184127</article-id><article-id pub-id-type="other">jnnp;81/3/315</article-id><article-id pub-id-type="other">jnnp;jnnp.2009.184127</article-id><article-id pub-id-type="pmid">19726415</article-id><article-id pub-id-type="other">315</article-id><article-id pub-id-type="other">jnnp.2009.184127</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Research paper</subject></subj-group></article-categories><title-group><article-title>Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ferrara</surname><given-names>Joseph</given-names></name></contrib><contrib contrib-type="author"><name><surname>Diamond</surname><given-names>Alan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>Christine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Davidson</surname><given-names>Anthony</given-names></name></contrib><contrib contrib-type="author"><name><surname>Almaguer</surname><given-names>Michael</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jankovic</surname><given-names>Joseph</given-names></name></contrib></contrib-group><aff>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</aff><author-notes><corresp><label>Correspondence to</label> Dr Joseph Jankovic, Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA; <email>josephj@bcm.tmc.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>1</day><month>9</month><year>2009</year></pub-date><volume>81</volume><volume-id pub-id-type="other">81</volume-id><volume-id pub-id-type="other">81</volume-id><issue>3</issue><issue-id pub-id-type="other">jnnp;81/3</issue-id><issue-id pub-id-type="other">3</issue-id><issue-id pub-id-type="other">81/3</issue-id><fpage>315</fpage><history><date date-type="received"><day>26</day><month>5</month><year>2009</year></date><date date-type="rev-recd"><day>9</day><month>7</month><year>2009</year></date><date date-type="accepted"><day>18</day><month>7</month><year>2009</year></date></history><permissions><copyright-statement>© 2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2010</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-81-315.pdf"></self-uri><abstract><sec><title>Objective</title><p>Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLS<sup>M</sup>, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance.</p></sec><sec><title>Methods</title><p>We prospectively analysed QLS<sup>M</sup> scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively.</p></sec><sec><title>Results</title><p>Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLS<sup>M</sup>. Specifically, QLS<sup>M</sup> items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve.</p></sec><sec><title>Conclusion</title><p>Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.</p></sec></abstract><kwd-group><kwd>Deep Brain Stimulation (DBS)</kwd><kwd>Parkinson's disease</kwd><kwd>quality of life</kwd><kwd>health status</kwd><kwd>QLS<sup>M</sup></kwd><kwd>movement disorders</kwd><kwd>neurosurgery</kwd><kwd>scales</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Ferrara</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alan</namePart><namePart type="family">Diamond</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Hunter</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Davidson</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Almaguer</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Joseph</namePart><namePart type="family">Jankovic</namePart><affiliation>Parkinson Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>E-mail: josephj@bcm.tmc.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2010-03</dateIssued><dateCreated encoding="w3cdtf">2009-09-01</dateCreated><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objective Advanced Parkinson's disease (PD) is associated with various motor and non-motor symptoms which adversely impact health-related quality of life (HRQoL). Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve some dimensions of HRQoL in appropriately selected candidates. Prior studies of HRQoL following DBS have used instruments comprising a predetermined list of questions which assess issues that are generally relevant in PD, but that may not be of equal or consistent importance to all individuals. In this study, we evaluate the effect of STN DBS on quality of life using the QLSM, a modular questionnaire in which satisfaction scores for each item are weighted in light of patient-rated importance. Methods We prospectively analysed QLSM scores in 21 patients with PD (11 men, mean age 61.5±8.6 years) before STN DBS surgery and at a mean 7.4±1.5, and again at a mean 16.6±6.8 months postoperatively. Results Following STN DBS, patients experienced an improvement in HRQoL as measured by various items of the movement disorder and health modules of the QLSM. Specifically, QLSM items pertaining to energy level/enjoyment of life, independence from help, controllability/fluidity of movement and steadiness when standing and walking showed significant improvements, although items concerning general life issues (eg, occupational function, interpersonal relationships, leisure activities) did not improve. Conclusion Following STN DBS, symptomatic and functional improvements translate into higher HRQoL, with high satisfaction in domains related to movement disorders and general health.</abstract><subject><genre>Keywords</genre><topic>Deep Brain Stimulation (DBS)</topic><topic>Parkinson's disease</topic><topic>quality of life</topic><topic>health status</topic><topic>QLSM</topic><topic>movement disorders</topic><topic>neurosurgery</topic><topic>scales</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>315</start></extent></part></relatedItem><identifier type="istex">C08850013797AFD8A24B99253A02F24B1CDF6385</identifier><identifier type="DOI">10.1136/jnnp.2009.184127</identifier><identifier type="href">jnnp-81-315.pdf</identifier><identifier type="ArticleID">jnnp184127</identifier><identifier type="PMID">19726415</identifier><identifier type="local">jnnp;81/3/315</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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